Effect of the course of treatment with broad-spectrum antibiotics on intestinal flora and short-chain fatty acids in feces of very low birth weight infants: a prospective study.
10.7499/j.issn.1008-8830.2107103
- Author:
Qian SUN
1
;
Zheng-Li WANG
1
;
Xiao-Chen LIU
1
;
Yan-Chun JI
1
;
Yu HE
1
;
Qing AI
1
;
Lu-Quan LI
1
Author Information
1. Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China (Li L-Q, Email: liluquan123@163.com).
- Publication Type:Journal Article
- Keywords:
Broad-spectrum antibiotics;
Intestinal flora;
Short-chain fatty acid;
Very low birth weight infant
- MeSH:
Anti-Bacterial Agents;
Child;
Fatty Acids, Volatile;
Feces;
Gastrointestinal Microbiome;
Humans;
Infant;
Infant, Newborn;
Infant, Very Low Birth Weight;
Prospective Studies
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(10):1008-1014
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the effect of the course of treatment with broad-spectrum antibiotics on intestinal flora and short-chain fatty acids (SCFAs) in feces of very low birth weight (VLBW) infants.
METHODS:A total of 29 VLBW infants who were admitted to the Neonatal Diagnosis and Treatment Center of Children's Hospital Affiliated to Chongqing Medical University from June to December 2020 were enrolled as subjects for this prospective study. According to the course of treatment with broad-spectrum antibiotics, they were divided into two groups: ≤7 days (
RESULTS:There was a significant reduction in Chao index of the intestinal flora in the ≤7 days group and the >7 days group from week 2 to week 4 (
CONCLUSIONS:The course of treatment with broad-spectrum antibiotics can affect the abundance, colonization, and evolution of intestinal flora and the content of their metabolites SCFAs in VLBW infants. The indication and treatment course for broad-spectrum antibiotics should be strictly controlled in clinical practice.
