Depressive males have higher odds of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a retrospective cohort study based on propensity score matching.
- Author:
Yang XIONG
1
;
Yang-Chang ZHANG
2
;
Tao JIN
3
;
Feng QIN
1
;
Jiu-Hong YUAN
1
Author Information
- Publication Type:Journal Article
- Keywords: aging males; benign prostatic hyperplasia; depression; lower urinary tract symptoms; propensity score matching
- MeSH: Aged; China/epidemiology*; Cohort Studies; Depression/epidemiology*; Humans; Logistic Models; Longitudinal Studies; Lower Urinary Tract Symptoms/etiology*; Male; Middle Aged; Propensity Score; Prostatic Hyperplasia/epidemiology*; Retrospective Studies
- From: Asian Journal of Andrology 2021;23(6):633-639
- CountryChina
- Language:English
- Abstract: Lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH) and depression are both increasing in Chinese aging males. However, the relationship still remains unknown. To explore their relationship, a retrospective cohort study based on propensity score matching (PSM) was conducted by analyzing the China Health and Retirement Longitudinal Study dataset. After data cleaning, a total of 5125 participants were enrolled and subjected to PSM; 1351 pairs were matched and followed for 2 years. Further logistic regression and restricted cubic spline (RCS) were performed to evaluate, model and visualize the relationship between depression and LUTS/BPH. Moreover, subgroup analyses and sensitivity analyses were adopted to verify the robustness of the conclusions. Before PSM, depressive patients showed higher odds of LUTS/BPH in all three models adjusting for different covariates (P < 0.001). After PSM, univariate logistic regression revealed that depressive patients had higher risks for LUTS/BPH than participants in the control group (odds ratio [OR] = 2.10, P < 0.001). The RCS results indicated a nonlinear (P < 0.05) and inverted U-shaped relationship between depression and LUTS/BPH. In the subgroup analyses, no increased risks were found among participants who were not married or cohabitating, received an education, had an abnormal body mass index (<18.5 kg m