Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatogonial stem cells.

Author: Ying-Hua WANG ¹ ; Meng YAN ¹ ; Xi ZHANG ² ; Xin-Yu LIU ¹ ; Yi-Fu DING ¹ ; Chong-Ping LAI ¹ ; Ming-Han TONG ² ; Jin-Song LI ¹
Author Information

1. State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
2. State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
Publication Type:Journal Article
Keywords: azoospermia; gene therapy; male infertility; meiotic arrest; spermatogonial stem cells; testis-expressed 11
MeSH: Adult Germline Stem Cells/metabolism*; Animals; Azoospermia/genetics*; Infertility, Male/therapy*; Male; Mice; Mutation/genetics*; Spermatogenesis/genetics*
From: Asian Journal of Andrology 2021;23(6):590-599
CountryChina
Language:English
Abstract: Azoospermia patients who carry a monogenetic mutation that causes meiotic arrest may have their biological child through genetic correction in spermatogonial stem cells (SSCs). However, such therapy for infertility has not been experimentally investigated yet. In this study, a mouse model with an X-linked testis-expressed 11 (TEX11) mutation (Tex11