Value of urine IL-8, NGAL and KIM-1 for the early diagnosis of acute kidney injury in patients with ureteroscopic lithotripsy related urosepsis.
10.1016/j.cjtee.2021.10.001
- Author:
Dan TAN
1
;
Liang ZHAO
1
;
Wei PENG
1
;
Fang-Hao WU
1
;
Guo-Bin ZHANG
1
;
Bo YANG
1
;
Wen-Qian HUO
2
Author Information
1. Department of Urology, The General Hospital of Chongqing Steel Company, Chongqing, 400081, China.
2. Department of Urology, The General Hospital of Chongqing Steel Company, Chongqing, 400081, China. Electronic address: wenqian1858@163.com.
- Publication Type:Journal Article
- Keywords:
Acute kidney injury;
Early diagnosis;
Interleukin-18;
Kidney injury molecule-1;
Neutrophil gelatinase-associated lipocalin;
Ureteroscopic lithotripsy;
Urosepsis
- MeSH:
Acute Kidney Injury/etiology*;
Biomarkers;
Early Diagnosis;
Hepatitis A Virus Cellular Receptor 1;
Humans;
Interleukin-18;
Interleukin-8;
Lipocalin-2;
Lithotripsy;
Retrospective Studies;
Ureteroscopy
- From:
Chinese Journal of Traumatology
2022;25(1):27-31
- CountryChina
- Language:English
-
Abstract:
PURPOSE:To investigate the clinical value of urine interleukin-18 (IL-8), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for the early diagnosis of acute kidney injury (AKI) in patients with ureteroscopic lithotripsy (URL) related urosepsis.
METHODS:A retrospective study was carried out in 157 patients with urosepsis after URL. The patients were divided into AKI group and non-AKI group according to the Kidigo guideline and urine IL-8, NGAL and KIM-1 levels were detected by enzyme-linked immunosorbent assay at 0, 4, 12, 24 and 48 h after the surgery. Receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of these three biomarkers for postoperative AKI.
RESULTS:The level of urine IL-8, NGAL and KIM-1 in AKI group was significantly higher than that in non-AKI group at 4, 12, 24 and 48 h (p < 0.01). The ROC analysis showed the combined detection of urine IL-8, NGAL and KIM-1 at 12 h had a larger area under curve (AUC) than a single marker (0.997, 95% CI: 0.991-0.998), and the sensitivity and specificity were 98.2% and 96.7%, respectively. Pearson correlation analysis showed that the levels of urine NGAL at 4, 12, 24 and 48 h in AKI patients were positively correlated with the levels of urine KIM-1 and IL-18 (p < 0.01).
CONCLUSION:AKI could be quickly recognized by the elevated level of urine IL-8, NGAL and KIM-1 in patients with URL-related urosepsis. Combined detection of the three urine biomarkers at 12 h after surgery had a better diagnostic performance, which may be an important reference for the early diagnosis of AKI.
