Predictive Value of Newly Diagnosed IgG Level in Patients with IgG-type Multiple Myeloma after Initial Treatment.
10.19746/j.cnki.issn.1009-2137.2021.06.023
- Author:
Qing LI
1
;
Chi-Ding HU
2
;
Chang-Chun ZHANG
1
;
Wei JIANG
1
;
Qing-Rui WANG
1
;
Yi-Chen SUN
1
;
Jin-Le YANG
3
Author Information
1. Department of Oncology, The Affiliated Hospital of Jianghan University, Wuhan 430015, Hubei Province, China.
2. Department of Oncology, The Affiliated Hospital of Jianghan University, Wuhan 430015, Hubei Province, China,E-mail: 764036070@qq.com.
3. Department of Hematology, The Second People's Hospital of Yichang, Yichang 443000, Hubei Province, China.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Hematopoietic Stem Cell Transplantation;
Humans;
Immunoglobulin G;
Multiple Myeloma/therapy*;
Transplantation, Autologous
- From:
Journal of Experimental Hematology
2021;29(6):1825-1830
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the predictive value of newly diagnosed IgG levels in the recurrence of IgG-type multiple myeloma (MM) patients after initial treatment.
METHODS:The clinical and pathological data of 91 patients newly diagnosed IgG-type MM who were hospitalized in the Department of Hematology of the Second People's Hospital of Yichang and Department of Oncology of The Affiliated Hospital of Jianghan University from April 2010 to March 2019 were collected. According to the median IgG level at the time of initial diagnosis, patients were divided into high IgG group and low IgG group. The recurrence time after initial treatment was followed up, and the correlation between newly diagnosed IgG level and recurrence was analyzed by univariate and multivariate analysis, as well as the influencing factors of IgG levels in order to predict furtherly the potential mechanism of recurrence.
RESULTS:Univariate survival analysis showed that high revised international staging system (R-ISS) staging, high level of bone marrow plasma cell (BMPC), lactate dehydrogenase (LDH), creatinine, β
CONCLUSION:The higher the serum IgG concentration of IgG-type MM patients at first diagnosis, the earlier the recurrence, which is related to the low level of serum albumin, and can be used as a potential recurrence predictor after complete remission of IgG-type MM patients.
