Inhibitory Effect of Continentalic Acid from Aralia continentalis on Streptococcus mutans Biofilm.
- Author:
Seung Il JEONG
1
;
Sang Bong LEE
;
Hae Dalma MOON
;
Ji Young RA
;
Kwang Hee LEE
;
Yong Ouk YOU
Author Information
1. Jeonju Biomaterials Institute, Korea.
- Publication Type:Original Article
- Keywords:
biofilm;
continentalic acid;
dental caries;
Streptococcus mutans
- MeSH:
1-Butanol;
Acetates;
Aralia;
Biofilms;
Biological Assay;
Chromatography;
Dental Caries;
Diterpenes;
Methanol;
Stomatognathic Diseases;
Streptococcus;
Streptococcus mutans;
Water
- From:International Journal of Oral Biology
2010;35(4):177-184
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In our present study, we investigated the effects of continentalic acid on Streptococcus mutans (S. mutans) biofilm. Methanol extract of Aralia continentalis (A. continentalis) was suspended in water and sequentially partitioned with CHCl3, ethyl acetate (EtOAc), and n-butanol (n-BuOH). The CHCl3 fraction showed the highest activity and an antibacterial compound against S. mutans was isolated from this preparation through various chromatography methods by bioassay guided fractionation. MS, 1H-NMR and 13C-NMR analysis showed that the active principle was continentalic acid which was confirmed to show significant inhibitory effects against S. mutans biofilm. These results may provide some scientific rationale for the traditional use these extracts for the treatment of dental diseases.
