Clinical Significance of EBV-DNA Copy Number in EBV Positive Lymphoma Patients.
10.19746/j.cnki.issn.1009-2137.2021.06.016
- Author:
Li-Hua QIU
1
;
Yue-Yang LI
1
;
Ya-Xin ZHENG
1
;
Tian YUAN
1
;
Sa DING
2
;
Zheng-Zi QIAN
1
;
Lan-Fang LI
1
;
Yu-Mei FENG
1
;
Hui-Lai ZHANG
1
;
Chen TIAN
3
Author Information
1. Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
2. Department of Oncology, Hotan District People's Hospital of Xinjiang, Hotan 848000, Xinjiang Uygur Autonomous Region, China.
3. Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China,Department of Oncology, Hotan District People's Hospital of Xinjiang, Hotan 848000, Xinjiang Uygur Autonomous Region, China,E-mail：tianchen@tjmuch.com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
DNA Copy Number Variations;
DNA, Viral;
Herpesvirus 4, Human;
Humans;
Lymphoma;
Middle Aged;
Retrospective Studies;
Young Adult
- From:
Journal of Experimental Hematology
2021;29(6):1785-1789
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of EBV-DNA copy number on the prognosis of patients with EBV positive lymphoma.
METHODS:Clinical data of 109 patients diagnosed as EBV positive lymphoma in Tianjin Medical University Cancer Institute and Hospital from January 2010 to January 2020 were enrolled and analyzed retrospectively. Kaplan-Meier analysis was used for survival analysis, Log-rank was used to compare the clinical characteristics between the patients in different groups, and Cox regression was used for multivariate analysis.
RESULTS:Among the 109 patients with EBV-positive lymphoma, the medium age were 56 (range 15 to 83) years old. 29 patients at Ann Arbor stage I-II while 80 patients at stage III-IV. The average value of EBV-DNA was 1 023 510 IU/ml, 7 patients were higher than the average value, while 102 patients were lower. KM survival analysis showed that OS and PFS in patients with EBV-DNA above average level were shorter than those in patients with EBV-DNA below average level (OS: P=0.048, PFS: P=0.001), EBV-DNA copy number was a factor affecting the prognosis of patients. In addition, LDH level showed positive correlation with EBV-DNA copy number (r=0.650), which was also one of the factors affecting OS (P=0.053).
CONCLUSION:EBV-DNA copy number and LDH level can influence the prognosis of EBV positive lymphoma patients. Therefore, detection of EBV-DNA copy number in peripheral blood is important for evaluate the prognosis the patients.
