Clinical and Cytogenetical Characteristics in Acute Myeloid Leukemia with Myelodysplasia-Related Changes.
10.19746/j.cnki.issn.1009-2137.2021.06.011
- Author:
Jin-Long MA
1
;
An-Qi ZHOU
1
;
Si-Yu GU
1
;
Bao-An CHEN
1
;
Zheng GE
2
Author Information
1. Department of Hematology of Zhongda Hospital, Medical School of Southeast University, Institute of Hematology Southeast University, Nanjing 210009, Jiangsu Province, China.
2. Department of Hematology of Zhongda Hospital, Medical School of Southeast University, Institute of Hematology Southeast University, Nanjing 210009, Jiangsu Province, China E-mail: gezheng2008@163.com.
- Publication Type:Journal Article
- MeSH:
Cytogenetic Analysis;
Cytogenetics;
Humans;
Leukemia, Myeloid, Acute/genetics*;
Middle Aged;
Myelodysplastic Syndromes/genetics*;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(6):1757-1762
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical and cytogenetic characteristics of acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) based on morphology define.
METHODS:A total of 180 newly diagnosed acute myeloid leukemia (AML) patients were enrolled and retrospectively analyzed, and marrow cell morphology of 126 patients were re-evaluated. The clinical and cytogenetic characteristics, including ages, sex, WBC count, HGB level, PLT count, blasts percentage, abnormal karyotype detection rate of the patients in AML with multilineage dysplasia (AML-MRC-1), secondary AML from myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) (AML-MRC-2), and AML not otherwise specified (AML-NOS) groups were investigated.
RESULTS:There was no significant differences between the patients in three groups in terms of sex, age and platelet count (P=0.898, P=0.365, P=0.853), but AML-MRC-2 group (73.2%) was higher than AML-MRC-1 (60.0%) and AML-NOS (56.4%) in the percentages of patients over 60 years old (P=0.228); there were statistically significant differences on WBC count, HGB level, and blasts percentage (P=0.000, P=0.022, P=0.000, AML-MRC-2
CONCLUSION:Morphological reassessment of bone marrow cell dysplasia is crucial to the differential diagnoses between AML-MRC (defined only by morphological changes of multilineage dysplasia) and AML-NOS. And the detection rate of cytogenetic abnormalities that mainly consisted of complex karyotypes and myelodysplasia-related abnormalities was higher in AML-MRC patients.
