Correlation of Plasma MiR-146a, MiR-223 Levels with the Prognosis of Childhood with Acute Lymphoblastic Leukemia.
10.19746/j.cnki.issn.1009-2137.2021.06.006
- Author:
Xiao-Yan HU
1
;
Jiao-Jiao YIN
2
;
Rong CHAO
1
;
Sheng-Dong ZHU
1
;
Wei DENG
1
;
Ming PAN
3
Author Information
1. Department of Pediatric General Medicine, Gansu Maternal and Child Health Hospital, Lanzhou 730050, Gansu Province, China.
2. Department of Laboratory Medicine, Gansu Maternal and Child Health Hospital, Lanzhou 730050, Gansu Province, China.
3. Department of Hematology, Wuwei People's Hospital, Wuwei 733000, Gansu Province, China,E-mail: gswwpm@126.com.
- Publication Type:Journal Article
- MeSH:
Child;
Humans;
MicroRNAs;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Prognosis;
ROC Curve
- From:
Journal of Experimental Hematology
2021;29(6):1727-1732
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression of plasma microRNA (miR)-146a and miR-223 in children with acute lymphoblastic leukemia (ALL), so as to analyze the relationship between the two factors and the prognosis of children with ALL.
METHODS:100 children with ALL treated in the hospital from January 2015 to December 2017 were selected, according to the standard of Chinese Children's Leukemia Group (CCLG)-ALL-2008 program, the children were performed standardized treatment in our hospital according to different risk degree, the follow-up results were obtained, the follow-up time was ≥36 months, and the follow-up time was till to March 2021, the recurrence and mortality of the children were used as prognostic indicators; the baseline data of the children at admission were inquired and recorded, the plasma miR-146a and miR-223 levels were analyzed at admission, and their correlation with the prognosis of children with ALL was analyzed.
RESULTS:During the follow-up period, 4 cases of children died while 18 cases recurred, which means 22(22.00%) children showed the poor prognosis; the plasma miR-146a level of the children in poor prognosis group at admission was higher than those in good prognosis group, while the plasma miR-223 level was lower than those in good prognosis group, the differences showed statistically significantly (P<0.05); the results of regression analysis showed that the over expression of plasma miR-146a and low expression of plasma miR-223 at admission might be associated with poor prognosis in ALL children, and might be a risk factor for poor prognosis in children (P<0.05); the ROC curve showed that the AUC of plasma miR-146a and miR-223 at admission alone or in combination showed the predictive value for the risk of poor prognosis in children with ALL(AUC >0.80); the results of correlation test showed that there was a negative correlation of plasma miR-146a with miR-223 levels at admission (r=-0.239, P=0.016).
CONCLUSION:Plasma miR-146a is overexpressed and miR-223 is low-expressed in children with ALL, the abnormal expression of the two factors is related to the prognosis of children with ALL.
