Research and Application Progress of Chitosan-based Hemostatic Materials---Review.
10.19746/j.cnki.issn.1009-2137.2021.05.052
- Author:
Ming-Zi MA
1
;
Yang YU
2
Author Information
1. Medical School of Chinese PLA, Department of Blood Transfusion Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
2. Medical School of Chinese PLA, Department of Blood Transfusion Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China E-mail: yuyangpla301@163.com.
- Publication Type:Journal Article
- MeSH:
Blood Coagulation;
Chitosan/pharmacology*;
Hemorrhage;
Hemostasis;
Hemostatics;
Humans
- From:
Journal of Experimental Hematology
2021;29(5):1685-1689
- CountryChina
- Language:Chinese
-
Abstract:
Whether in war or peace, timely, effective and accurate hemostasis is an important measure to improve the survival rate and cure rate of the wounded. All the countries in the world are actively developing different types of hemostatic materials so as to reduce the amount of bleeding in an emergency and create favorable conditions for subsequent transport and treatment. At present, the commercialized hemostatic materials are mainly divided into natural biological, synthetic biological, mineral and coagulation components, but all these materials have their own limitations. In this article, the characteristics of chitosan and its derivatives are reviewed as the representatives of the natural organic macromolecular polysaccharide hemostasis materials. Their molecular structures, biomedical properties, domestic and foreign research and application progress as well as comparison with applications of other hemostatic materials are involved. The further research is prospected for optimization and innovation to develop composite chitosan hemostatic materials with the function of hemostasis, antibiosis, pain relief and promoting wound healing.
