Research Progress of in Vitro Experiment of Allergic Transfusion Reaction for Plasma Transfusion and Its Relative Mechanism---Review.
10.19746/j.cnki.issn.1009-2137.2021.05.047
- Author:
Chao-Yun XI
1
;
Chun-Ya MA
1
;
Hong-Fei ZHANG
1
;
Chao WEI
2
;
De-Qing WANG
3
Author Information
1. Department of Blood Transfusion, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
2. Department of Blood Transfusion, Beijing Electrical Hospital Affiliated to Capital Medical University, Beijing 100073, China.
3. Department of Blood Transfusion, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China E-mail: deqingw@vip.sina.com.
- Publication Type:Journal Article
- MeSH:
Blood Component Transfusion;
Blood Transfusion;
Humans;
Hypersensitivity;
Plasma;
Transfusion Reaction
- From:
Journal of Experimental Hematology
2021;29(5):1662-1666
- CountryChina
- Language:Chinese
-
Abstract:
Allergic transfusion reaction (ATR) caused by plasma transfusion is one of the main adverse transfusion reactions, and severe allergic reactions may even endanger the patient's life. Currently, ATR is mainly prevented and controlled by drug prevention and symptomatic treatment, and there still lack of preventive measures such as in vitro experiments. It has been shown that mast cells and basophils are the main effector cells of allergic reactions, and histamine is one of the main mediators of IgE-mediated allergic reactions. Some experiments can be used to identify patients with allergies or plasma components containing allergens, such as detection of serum-specific IgE, IgA, anti-IgA antibody, tryptase and histamine, mast cell degranulation test, basophil activation test, and so on. The basophil activation test can also be used for functional matching of plasma in vitro. Research of in vitro experiment of ATR is good for directing the precise infusion of plasma, reducing waste of resources, and avoiding the risk of blood transfusion. As a pre-transfusion laboratory test for clinical use, in vitro experiment of functional matching provides a new way to prevent ATR.
