Infection in Children with Acute Myeloid Leukemia in the Intensive Chemotherapy Period.
10.19746/j.cnki.issn.1009-2137.2021.05.044
- Author:
Kai Lan CHEN
1
;
Hao XIONG
1
;
Jian Xin LI
1
;
Fang TAO
1
;
Bing WU
1
;
Zhuo WANG
1
;
Ying Ming NIE
1
;
Hui LI
2
Author Information
1. Department of Hematology and Oncology， Wuhan Children's Hospital， Tongji Medical College， Huazhong University of Science & Technology， Wuhan 430016， Hubei Province, China.
2. Department of Hematology and Oncology， Wuhan Children's Hospital， Tongji Medical College， Huazhong University of Science & Technology， Wuhan 430016， Hubei Province, China,Email：tianyirabbit@163.com.
- Publication Type:Journal Article
- MeSH:
Antifungal Agents/therapeutic use*;
Child;
Fever/drug therapy*;
Humans;
Leukemia, Myeloid, Acute/drug therapy*;
Mycoses/drug therapy*;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(5):1649-1653
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical characteristics of infection in children with acute myeloid leukemia (AML) after high intensive chemotherapy， so as to provide reference for prevention and control of infection.
METHODS:56 children diagnosed as acute myeloid leukemia in our hospital from January 2016 to August 2019 were enrolled and retrospectively analyzed, the infection rate, pathogens of disease and common location of infection during the induction and consolidation period were analyzed.
RESULTS:The total infection rate of the patients was 93.4%－96.4%, the average of serious infection rate was 16.0%(11.3%－19.6%), and the infection related mortality was 10.7%. Fever of unknown cause was the main reason of infection, while blood flow infections were the most common in severe infection, which were mainly caused by Gramnegative bacteria. The rate of fungal infection was 35.7% during chemotherapy.
CONCLUSION:Children with AML shows a high incidence of infection in each stage of chemotherapy. The serious illness caused by blood flow infection and take antifungal drugs to reduce the occurrence of fungal infection in AML patients should be paid attention.
