The Clinical Characteristics and Outcomes of the Patients with POEMS Syndrome.
10.19746/j.cnki.issn.1009-2137.2021.05.043
- Author:
Meng WANG
1
;
Jing-Lan ZHANG
1
;
Ding-Ming WAN
1
;
Rong GUO
1
;
Yuan-Dong CHENG
1
;
Zhong-Xing JIANG
2
Author Information
1. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
2. Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China E-mail: Jiangzx1266@163.com.
- Publication Type:Journal Article
- MeSH:
Aged;
Aged, 80 and over;
Hematopoietic Stem Cell Transplantation;
Humans;
Lenalidomide;
Middle Aged;
POEMS Syndrome/therapy*;
Retrospective Studies;
Transplantation, Autologous
- From:
Journal of Experimental Hematology
2021;29(5):1645-1648
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the clinical characteristics of patients with POEMS syndrome and explore its effective treatment strategies.
METHODS:The clinical data of 75 patients with POEMS syndrome treated in The First Affiliated Hospital of Zhengzhou University from June 2012 to June 2018 were collected and retrospectively analyzed. The clinical characteristics, treatment regimes and outcomes of the patients were summarized.
RESULTS:The median age of 75 diagnosed patients was 50 (30-81) years old and 100% (75/75) of the patients were accompanied with peripheral neuropathy, 77.3% (58/75) with organ enlargement, 82.7% (62/75) with endocrine abnormality, 93.3% (70/75) with monoclonal plasma cell diseases and 64.0% (48/75) with skin changes. Among the 75 patients, 5 cases gave up treatment, while the others showed varying degrees of improvement after treatment. The hematological complete remission (CR
CONCLUSION:The clinical manifestations of POEMS syndrome are complex and diverse, the clinicians therefore should be vigilant to reduce the misdiagnosis and missed diagnosis. Bortezomib or Lenalidomide can be recommended as the first-line medicines and autologous HSCT should be considered for appropriate patients.
