Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation.
10.19746/j.cnki.issn.1009-2137.2021.05.023
- Author:
Mei-Rong ZANG
1
;
Lan-Ting LIU
2
;
Shu-Hui DENG
2
;
Lu-Gui QIU
3
Author Information
1. Department of Hematology, The Third Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China.
2. Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin 300020, China.
3. Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin 300020, China E-mail: qiulg@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
Cell Cycle Proteins;
Cell Proliferation;
Chaperonins;
Humans;
Mice;
Mice, Inbred NOD;
Mice, SCID;
Multiple Myeloma
- From:
Journal of Experimental Hematology
2021;29(5):1522-1527
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of cell division cycle protein 37 (Cdc37) in multiple myeloma (MM) and its effect on MM cell proliferation.
METHODS:The expression of Cdc37 mRNA in CD138
RESULTS:Cdc37 was highly expressed in newly diagnosed CD138
CONCLUSION:Cdc37 is highly expressed in newly diagnosed MM patients. Inhibition of Cdc37 results in decreased proliferation activity and G
