Clinical Significance of Tfh/Tfr Cell Imbalance in Patients with B-Cell Lymphoma.
10.19746/j.cnki.issn.1009-2137.2021.05.021
- Author:
Jing ZHENG
1
;
Zhu ZHANG
1
;
Yong-Hong CHEN
1
;
Yao XIAO
1
;
Rong SHEN
1
;
Lin WANG
1
;
Ping ZHANG
1
;
Qian-Yun YANG
2
;
Chun FENG
1
;
Kai-Bo GAO
3
Author Information
1. Department of Hematology, The First People's Hospital of Yichang, China Three Gorges University,Yichang 443000, Hubei Province, China.
2. Department of Obstetrics, The Second People's Hospital of Yichang, Yichang 443000, Hubei Province, China.
3. Department of Hematology, The First People's Hospital of Yichang, China Three Gorges University,Yichang 443000, Hubei Province, China,E-mail: 2263512712@qq.com.
- Publication Type:Journal Article
- MeSH:
Flow Cytometry;
Humans;
Lymphoma, B-Cell;
T Follicular Helper Cells;
T-Lymphocytes, Helper-Inducer;
T-Lymphocytes, Regulatory
- From:
Journal of Experimental Hematology
2021;29(5):1510-1516
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the role of follicular helper T cell (Tfh)/ follicular regulatory T cell (Tfr) imbalance in B-cell lymphoma (BCL).
METHODS:Sixteen BCL patients who were admitted to the Department of Hematology of The First People's Hospital of Yichang and 20 healthy people from December 2019 to November 2020 were enrolled and respectively divided into observation group and control group. The levels of Tfh and Tfr in peripheral blood were detected by flow cytometry. The changes of Tfh, Tfr, and Tfh/Tfr ratio were compared and the relationship between Tfh/Tfr ratio and efficacy, prognosis was analyzed.
RESULTS:Compared with the healthy controls, Tfh and Tfh/Tfr ratio in peripheral blood of the BCL patients increased (P<0.05, P<0.01), while levels of Tfr was decreased (P<0.01). After chemotherapy, Tfh and Tfh/Tfr ratio in peripheral blood of the BCL patients decreased significantly than before chemotherapy (P<0.01), but Tfr was no significant difference. Multivariate analysis showed that Tfh and Tfh/Tfr ratio were positively correlated with international prognostic index (IPI) score and Ann Arbor stage (r=0.626, 0.564, 0.573, 0.608, respectively), while Tfr negatively (r=－0.504, －0.542, respectively). According to the average value of Tfh/Tfr ratio at initial diagnosis, BCL patients were divided into Tfh/Tfr high ratio group and low ratio group. It was found that the complete remission (CR) rate, overall response rate (ORR), and survival time in the high ratio group were significantly lower than the low ratio group (P<0.01).
CONCLUSION:There is an imbalance of Tfh/Tfr ratio in peripheral blood of the BCL patients, and those with a high Tfh/Tfr ratio have lower CR, ORR and shorter survival time.
