Effects of Arsenic Disulfide Combined with Itraconazole on Proli- feration and Apoptosis and Hedgehog Pathway of Diffuse Large B-Cell Lymphoma Cells.
10.19746/j.cnki.issn.1009-2137.2021.05.020
- Author:
Ling WANG
1
;
Shi-Quan DING
2
;
Hua-Wei LI
3
;
Sheng-Hong DU
4
;
Chen CHEN
4
;
Yu-Yu LIU
4
;
Ban-Ban LI
4
;
Cong LIU
4
;
Jun JIAO
4
;
Qing-Liang TENG
4
Author Information
1. Department of Hematology, Taian City Central Hospital, Taian 271000, Shandong Province, China,E-mail: wangl77@163.com.
2. Department of Hematology, Taian City Central Hospital, Taian 271000, Shandong Province, China,Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, Shandong Province, China.
3. Department of Information Center, Taian City Central Hospital, Taian 271000, Shandong Province, China.
4. Department of Hematology, Taian City Central Hospital, Taian 271000, Shandong Province, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Arsenicals;
Hedgehog Proteins;
Humans;
Itraconazole/pharmacology*;
Lymphoma, Large B-Cell, Diffuse/drug therapy*;
Sulfides
- From:
Journal of Experimental Hematology
2021;29(5):1504-1509
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of arsenic disulfide (AS
METHODS:The human DLBCL cell OCI-LY3 was treated with different concentrations of AS
RESULTS:The DLBCL cell viability was decreased significantly at 24, 48 or 72 h as cultured with itraconazole. Along with the increasing of itraconazole concentration, the DLBCL cell viability was significantly reduced as compared with that in control group, and the results showed statistically significant(r=-0.690，r=-0.639, r=-0.833, r=-0.808, r=-0.578). The inhibitory and apoptosis rates of the cells were significantly increased as compared with those of the single drug-treated group after treated by the combination of itraconazole and AS
CONCLUSION:Itraconazole can inhibit proliferation of DLBCL cells in a concentration-and time-dependent manner. In addition, the combination of AS
