Natural medicinal ingredients induce tumor ferroptosis and related mechanisms.
10.3724/zdxbyxb-2021-0198
- Author:
Zixue XUAN
1
;
Yiwen ZHANG
1
;
Zongfu PAN
1
;
Xiaowei ZHENG
1
;
Ping HUANG
1
Author Information
1. Department of Pharmacy, Clinical Pharmacy Center, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
- Publication Type:Review
- Keywords:
Ferroptosis;
Natural medicine;
Regulatory mechanism;
Review;
Traditional Chinese medicine;
Tumor
- MeSH:
Apoptosis;
Autophagy;
Ferroptosis;
Humans;
Neoplasms/drug therapy*;
Reactive Oxygen Species
- From:
Journal of Zhejiang University. Medical sciences
2021;50(5):601-606
- CountryChina
- Language:English
-
Abstract:
Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxide accumulation, which is different from cell apoptosis, pyroptosis, necrosis or autophagy. Ferroptosis plays an important role in the regulation of tumorigenesis and tumor development. Recent studies have shown that natural medicinal ingredients can induce ferroptosis in tumor cells through glutathione (GSH)/glutathione peroxidase 4 (GPx4) pathway, iron metabolism, lipid metabolism or other mechanisms. It has been reported that more than 30 natural medicinal ingredients can induce ferroptosis in tumor cells with multiple pathways and multiple targets. This article reviews the current research progress on the antitumor effects of natural medicinal ingredients through inducing cell ferroptosis.
