The roles of GluN3-containing N-methyl-D-aspartate receptor in central nerve system.
10.3724/zdxbyxb-2021-0167
- Author:
Qi SUN
1
;
Wei CAO
1
;
Jianhong LUO
1
Author Information
1. School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Review
- Keywords:
GluN3 subunit;
Mental disorder;
N-methyl-D-aspartate receptor;
Neural development;
Review;
Synaptic pruning
- MeSH:
Central Nervous System/metabolism*;
Protein Subunits/metabolism*;
Receptors, N-Methyl-D-Aspartate;
Synapses
- From:
Journal of Zhejiang University. Medical sciences
2021;50(5):651-658
- CountryChina
- Language:English
-
Abstract:
The N-methyl-D-aspartate receptor (NMDAR) in central nerve system is mostly composed of GluN1 and GluN2 subunits. The classical NMDAR has been intensively studied. However, GluN3‑containing NMDAR is much less expressed and have atypical channel properties. Recently, accumulating evidences have revealed two types of GluN3‑containing NMDAR: glutamate-gated GluN1/GluN2/GluN3 NMDAR and glycine-gated GluN1/GluN3 NMDAR. The former may play important roles in regulating synapse maturation and pruning non-used synapses, and its elevated expression at the adult stage may alter synaptic reorganization in some neuropsychiatric disorders. The latter is expressed in the medial habenula and involves in control of aversion. This article reviews the recent progresses on the expression, functional properties of GluN3‑containing atypical NMDARs and the physiological and pathological relevance.
