The roles of epigenetic modifications in neurodegenerative diseases.
10.3724/zdxbyxb-2021-0160
- Author:
Wenzheng QU
1
;
Yingliang ZHUANG
1
;
Xuekun LI
1
Author Information
1. of Translational Medicine, Zhejiang University, Hangzhou 310029, China.
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
DNA modification;
Epigenetics;
Histone modification;
Huntington’s disease;
Parkinson’s disease;
RNA modification;
Review
- MeSH:
Animals;
DNA Methylation;
Epigenesis, Genetic;
Humans;
Neurodegenerative Diseases/genetics*;
Parkinson Disease/genetics*;
Protein Processing, Post-Translational
- From:
Journal of Zhejiang University. Medical sciences
2021;50(5):642-650
- CountryChina
- Language:English
-
Abstract:
In neuronal system, epigenetic modifications are essential for neuronal development, the fate determination of neural stem cells and neuronal function. The dysfunction of epigenetic regulation is closely related to occurrence and development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease. Abnormally elevated DNA methylation inhibits the expression of some DNA repair-related genes and affects the progression of Huntington's disease. In the brain of Alzheimer's disease patients, the levels of H3K27ac and H3K9ac histone modifications increased. In addition, the alteration of RNA methylation in animal models of Alzheimer's disease and Parkinson's disease showed discrepancy trends. Therefore, epigenetic modifications may serve as potential therapeutic targets for neurodegenerative diseases. Here, we summarize the recent progress of the roles of epigenetic modifications in neurodegenerative diseases.
