Research Progress of Circular RNAs in Tumor Immunotherapy.
10.3779/j.issn.1009-3419.2021.101.31
- Author:
Chenyu ZHANG
1
;
Lei PENG
1
;
Jingbin JI
1
;
Wenjie JIAO
1
Author Information
1. Department of Thoracic Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266071, China.
- Publication Type:Journal Article
- Keywords:
Circular RNAs;
Immune checkpoint;
Lung neoplasms;
Tumor;
Tumor immunotherapy
- MeSH:
Biomarkers, Tumor;
Humans;
Immunotherapy;
Lung Neoplasms/therapy*;
Prognosis;
RNA, Circular
- From:
Chinese Journal of Lung Cancer
2021;24(10):698-704
- CountryChina
- Language:Chinese
-
Abstract:
Tumor immunotherapy is a new therapy which developed in recent years, it has greatly changed the therapeutic schedules and brought new options for patients. However, not all patients can have obvious therapeutic effects after using immunotherapy. So selecting more suitable patients and raising immunotherapy effect are worthy to discuss. With the research of circular RNAs (circRNAs), circRNAs have been found that they not only play a significant role in the field of tumor markers, tumor progression and prognosis, but also can abnormally express in a variety of tumors and affect tumor immunity. Therefore, the circRNAs expression may not only can be used as a supplementary method for selecting patients, but also can be used to predict the efficacy of tumor immunotherapy. In this article, we summarize current knowledge on circRNAs abnormally expressed in many cancers, especially lung cancer which can affect tumor immunity, and discuss its potential effects in tumor immunotherapy, and we hope to provide more references for the clinical practice of circRNAs.
.
