Research Advance of the Roles of N6-methyladenosine in the Regulation of Hematopoiesis--Review.
10.19746/j.cnki.issn.1009-2137.2021.06.049
- Author:
Ni-Ni WANG
1
;
Ya-Pu LI
1
;
Tao CHENG
2
,
3
;
Hui CHENG
2
,
4
Author Information
1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.
2. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College National Clinical Research Center for Blood Diseases
3. Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China.E-mail: chengtao@ihcams.ac.cn.
4. Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China.E-mail: chenghui@ihcams.ac.cn.
- Publication Type:Review
- MeSH:
Adenosine/metabolism*;
Hematopoiesis;
Humans;
Methylation;
RNA/metabolism*
- From:
Journal of Experimental Hematology
2021;29(6):1972-1976
- CountryChina
- Language:Chinese
-
Abstract:
There are more than 150 types of chemical modifications in RNA, mainly methylation, which are widely distributed in all kinds of RNA, including messenger RNA, transfer RNA, ribosomal RNA, non-coding small RNA and long non-coding RNA. In recent years, the identification of RNA methylation modification enzymes and the development of high-throughput sequencing technology at transcriptome level laid a foundation for revealing the expression and function of genes regulated by chemical modification of RNA. In this review, the most recent advances of RNA methylation, especially N6-methyladenosine (m
