Analysis of Factors Influencing Autologous Peripheral Blood Stem Cells Mobilization in Patients with Lymphoma and Multiple Myeloma.
10.19746/j.cnki.issn.1009-2137.2021.06.044
- Author:
Yong-Feng SU
1
;
Yi-Zhi WANG
1
;
Hong-Mei NING
1
;
Liang-Ding HU
2
Author Information
1. Department of Hematopoietic Stem Cell Transplantation, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China.
2. Department of Hematopoietic Stem Cell Transplantation, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China.E-mail: Huliangding@sohu.com.
- Publication Type:Journal Article
- MeSH:
Hematopoietic Stem Cell Mobilization;
Humans;
Lymphoma/therapy*;
Multiple Myeloma/therapy*;
Peripheral Blood Stem Cells;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(6):1945-1949
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the factors influencing the mobilization of autologous peripheral blood stem cells (auto-PBSCs) in patients with lymphoma and multiple myeloma, and provide reference for optimizing the autologous stem cell mobilization regimen.
METHODS:Clinical data of 33 multiple myeloma and lymphoma patients received auto-PBSCs mobilization in our center from January 2015 to December 2018 were collected, the correlation of mobilization failure rate with gender, age, courses of chemotherapy before mobilization, does of recombinant human granulocyte colony stimulating factor (rhG-CSF), type of disease, and chemotherapy regimen were retrospectively analyzed.
RESULTS:Type of disease and course of pre-mobilization chemotherapy could affect the mobilization failure rate (P<0.05). The mobilization failure rate of lymphoma patients was 42.1%, which was significantly higher than 7.1% of multiple myeloma patients (P=0.026). The mobilization failure rate was higher in the group with chemotherapy courses≥5 before mobilization (P=0.016). Age, gender, dose of rhG-CSF, and chemotherapy regimen had no significant correlation with mobilization failure rate (P>0.05).
CONCLUSION:Multi-course chemotherapy before collection and lymphoma patients are poor factors negatively impacting on auto-PBSCs mobilization.
