Transfusion Strategy for Rare Anti-LW Antibody Autoimmune Hemolytic Anemia Patients with Neonatal Hemolytic Disease.
10.19746/j.cnki.issn.1009-2137.2021.06.042
- Author:
Dong-Dong TIAN
1
;
Ding ZHAO
2
;
Zhi-Hao LI
1
;
Wei LI
1
;
Jia-Li YANG
1
;
Xiao-Pan ZHANG
1
;
Liu-Chuang ZHENG
1
Author Information
1. Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou 450018, Henan Province, China.
2. Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou 450018, Henan Province, China,E-mail: zhaoding2004@163.com.
- Publication Type:Journal Article
- MeSH:
Anemia, Hemolytic, Autoimmune;
Autoantibodies;
Blood Group Incompatibility;
Blood Transfusion;
Erythroblastosis, Fetal;
Humans
- From:
Journal of Experimental Hematology
2021;29(6):1935-1939
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the causes of positive irregular antibody screening test and incompatibility of cross matching in one patient with autoimmune hemolytic anemia complicated with neonatal hemolytic disease, and to accurately identify the type of antibodies in patients, and to select a reasonable strategy for blood transfusion.
METHODS:One children was enrolled, blood group positive and reverse typing, Rh typing, direct anti-human globulin test, free test, dispersal test and cross matching test were carried out by test tube method and microcolumn gel card; irregular antibodies were identified by the reaction of DTT treatment and untreated panel cells with patients' plasma.
RESULTS:The blood group of the patient was RhD positive B and irregular antibody screening positive, while the blood group of the mother was RhD positive O and irregular anti-screening negative, the result showed that the anti-LW detected in the plasma of the patient was autoantibody and ABO neonatal hemolytic disease (ABO-HDN) was present. Both O type RhD positive washing RBCs and B type RhD negative RBCs were transfused effectively.
CONCLUSION:Irregular antibodies in patients are anti-LW antibodies, and transfusion of homotype RhD negative suspended erythrocytes after the exclusion of ABO-HDN shows a better effect.
