Analysis of Thalassemia Gene Carriers in 19 482 Pregnant Women from 2015 to 2019 in Guilin, Guangxi.
10.19746/j.cnki.issn.1009-2137.2021.06.034
- Author:
Hai-Qing ZHENG
1
;
Xiang-Yuan YU
2
;
Dan ZENG
1
;
Qiao FENG
1
;
Chun-Jiang ZHU
3
Author Information
1. Department of Genetics and Precision Medicine Laboratory, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China.
2. Department of Epidemiology and Health Statistics, School of Public Health, Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China.
3. Department of Genetics and Precision Medicine Laboratory, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China.E-mail: zcjiang2003@qq.com.
- Publication Type:Journal Article
- MeSH:
China;
Female;
Genotype;
Heterozygote;
Humans;
Pregnancy;
Pregnant Women;
alpha-Thalassemia/genetics*
- From:
Journal of Experimental Hematology
2021;29(6):1892-1895
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the types and frequencies of thalassemia genes carried by the pregnant women in Guilin, Guangxi Zhuang Autonomous Region, China.
METHODS:From January 2015 to December 2019, blood samples of the pregnant women who visited the Outpatients of Obstetrics clinic and Eugenics Genetic clinic in Affiliated Hospital of Guilin Medical University were collected. Gap-PCR was used to detect deletional α-thalassemia, PCR-RDB to detect the gene mutations of non-deletional α-thalassemia and β-thalassemia, and MLPA or DNA sequencing to detect rare thalassemia mutations. Different types and frequencies of thalassemia mutations carried by pregnant women were analyzed statistically.
RESULTS:A total of 19 482 blood samples were collected, including 3 801 thalassemia gene carriers (19.51%). Seven types of α-thalassemia gene mutation were detected with a carrier rate of 15.43%. Among them, --
CONCLUSION:Guilin is a high-risk area for thalassemia. Alpha-thalassemia is dominated by --
