Gene Mutation Types and Ethnic Distribution Characteristic of Thalassemia in Guiyang.
10.19746/j.cnki.issn.1009-2137.2021.06.033
- Author:
Fang WANG
1
;
Ru-Yi ZHANG
2
;
Dong-Yang DENG
2
;
Di XU
1
;
Yan ZOU
1
;
Yi-Yuan ZHOU
3
Author Information
1. Graduate School of Guizhou University of Traditional Chinese Medicine,Guiyang 550002，Guizhou Province, China.
2. Department of Obstetrics, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550002，Guizhou Province, China.
3. The Center for Eugenics Research of The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine，Guiyang 550002，Guizhou Province, China. E-mail:1985825741@qq.com.
- Publication Type:Journal Article
- MeSH:
China;
Ethnic and Racial Minorities;
Ethnicity;
Female;
Humans;
Mutation;
Pregnancy;
alpha-Thalassemia/genetics*
- From:
Journal of Experimental Hematology
2021;29(6):1887-1891
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the genetic mutation types and ethnic distribution characteristics of thalassemia in Guiyang.
METHODS:The population underwent physical examination, antenatal examination and pre-pregnancy examination in our hospital from January 2019 to November 2019 was selected, and the thalassemia gene was detected by RDB-PCR.
RESULTS:Among the 4 572 samples, 346 were positive , and the total carrying rate was 7.57%. The carrying rate of α-thalassaemia gene was 5.42% (248 cases), while β-thalassemia was 1.99% (91 cases), and α+β-compound thalassemia was 0.15% (7 cases). α-thalassaemia genotype with the lack of right side -α
CONCLUSION:The gene types of thalassemia in Guiyang are complex and varied. The -α
