Early life blood lead levels and asthma diagnosis at age 4-6 years.
10.1186/s12199-021-01033-0
- Author:
Marina Oktapodas FEILER
1
;
Carly J PAVIA
2
;
Sean M FREY
3
;
Patrick J PARSONS
4
;
Kelly THEVENET-MORRISON
5
;
Richard L CANFIELD
6
;
Todd A JUSKO
7
Author Information
1. Department of Epidemiology and Biostatistics, College of Public Health, Temple University, 1301 Cecil B. Moore Ave, Philadelphia, PA, 19122, USA. marina.feiler@temple.edu.
2. Ramboll US Consulting Inc., 201 California St. #1200, San Francisco, CA, 94111, USA.
3. Department of Pediatrics, University of Rochester Medical Center, University of Rochester, 265 Crittenden Blvd, Rochester, NY, 14642, USA.
4. Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY, 12201, USA.
5. Department of Public Health Sciences, University of Rochester Medical Center, University of Rochester, 265 Crittenden Blvd, Rochester, NY, 14642, USA.
6. Division of Nutritional Sciences, Cornell University, M Van Rensselaer Hall, Ithaca, NY, 14853, USA.
7. Department of Environmental Medicine, University of Rochester Medical Center, University of Rochester, 601 Elmwood Ave, Rochester, NY, 14642, USA.
- Publication Type:Journal Article
- Keywords:
Metals;
Pediatric;
Respiratory disease;
Rochester
- MeSH:
Asthma/etiology*;
Child;
Child, Preschool;
Cohort Studies;
Environmental Pollutants/blood*;
Female;
Humans;
Infant;
Infant, Newborn;
Lead/blood*;
Male;
New York/epidemiology*
- From:Environmental Health and Preventive Medicine
2021;26(1):108-108
- CountryJapan
- Language:English
-
Abstract:
The USA has a high burden of childhood asthma. Previous studies have observed associations between higher blood lead levels and greater hypersensitivity in children. The objective of the present study was to estimate the association between blood lead concentrations during early childhood and an asthma diagnosis between 48 and 72 months of age amongst a cohort with well-characterized blood lead concentrations. Blood lead concentrations were measured at 6, 12, 18, 24, 36, and 48 months of age in 222 children. The presence of an asthma diagnosis between 48 and 72 months was assessed using a questionnaire which asked parents or guardians whether they had been told by a physician, in the past 12 months, that their child had asthma. Crude and adjusted risk ratios (RR) of an asthma diagnosis were estimated for several parameterizations of blood lead exposure including lifetime average (6 to 48 months) and infancy average (6 to 24 months) concentrations. After adjustment for child sex, birthweight, daycare attendance, maternal race, education, parity, breastfeeding, income, and household smoking, age-specific or composite measures of blood lead were not associated with asthma diagnosis by 72 months of age in this cohort.
