Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries.

Yuki Mizuno; Hana Shimizu-furusawa; Shoko Konishi; Tsukasa Inaoka; Sk Akhtar Ahmad; Makiko Sekiyama; Oekan S Abdoellah; Budhi Gunawan; Rajendra Prasad Parajuli; Yukio Ikemoto; Tran Dinh Lam; Chiho Watanabe; Masahiro Umezaki

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Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries.

Author: Yuki MIZUNO ¹ ; Hana SHIMIZU-FURUSAWA ² ; Shoko KONISHI ³ ; Tsukasa INAOKA ⁴ ; Sk Akhtar AHMAD ⁵ ; Makiko SEKIYAMA ⁶ ; Oekan S ABDOELLAH ⁷ ; Budhi GUNAWAN ⁷ ; Rajendra Prasad PARAJULI ⁸ ; Yukio IKEMOTO ⁹ ; Tran Dinh LAM ¹⁰ ; Chiho WATANABE ¹¹ ; Masahiro UMEZAKI ³
Author Information

1. Department of Human Ecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. mizuno@humeco.m.u-tokyo.ac.jp.
2. Department of Analytic Human Pathology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-8602, Japan.
3. Department of Human Ecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
4. Department of Human Ecology, Faculty of Agriculture, Saga University, 1 Honjo Machi, Saga, 840-0052, Japan.
5. Department of Occupational and Environmental Health, Bangladesh University of Health Sciences (BUHS), Darus Salam Mirpur-1, Dhaka, 1216, Bangladesh.
6. Health and Environmental Risk Division, National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, Ibaraki, 305-8506, Japan.
7. Department of Anthropology, Faculty of Social and Political Science, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21 Jatinangor, Sumedang, West Java Province, 45363, Indonesia.
8. Central Department of Zoology, Central Campus, Institute of Science & Technology (IOST), Tribhuvan University, Kritipur-1, Kathmandu, Nepal.
9. Institute for Advanced Studies on Asia, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
10. Center for Vietnamese and Southeast Asian Studies, Vietnam National University of Social Sciences and Humanities, 10-12 Dinh Tien Hoang, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.
11. School of Tropical Medicine and Global Health, Nagasaki University (NCGM Satellite), 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Publication Type:Journal Article
Keywords: Arsenic; Blood pressure; Cadmium; Lead; Selenium
MeSH: Adult; Arsenic/urine*; Bangladesh; Blood Pressure; Cadmium/urine*; Cross-Sectional Studies; Environmental Exposure; Female; Humans; Indonesia; Lead/urine*; Linear Models; Male; Metals, Heavy/urine*; Middle Aged; Nepal; Selenium/urine*; Vietnam
From:Environmental Health and Preventive Medicine 2021;26(1):101-101
CountryJapan
Language:English
Abstract: BACKGROUND:Previous studies have suggested that exposures to heavy metals (arsenic, cadmium, lead, and selenium) may be associated with differences in blood pressure. However, the findings of these studies have been inconsistent. This study was performed to examine the associations between urinary heavy metal concentrations and blood pressure among residents of four Asian countries (Bangladesh, Indonesia, Nepal, and Vietnam).
METHODS:This cross-sectional study examined 1899 adults in four Asian countries. Urinary concentrations of heavy metals were measured by inductively coupled plasma mass spectrometry. A questionnaire survey was administered regarding individual characteristics. Anthropometric measurements (height and weight) were performed. Systolic and diastolic blood pressures were measured after a short rest. Multiple linear regression models were applied to investigate associations between urinary heavy metal concentrations and blood pressure after adjustments for age, sex, and body mass index.
RESULTS:The geometric means of the urinary concentrations of arsenic, cadmium, lead, and selenium were 84.6, 0.885, 2.09, and 16.5 μg/g creatinine, respectively. The urinary arsenic concentrations were slightly higher than those typically reported in non-polluted populations, while urinary cadmium, lead, and selenium concentrations were equivalent or slightly lower. The urinary lead concentrations were positively associated with both systolic and diastolic blood pressure, but urinary selenium concentrations were negatively associated with them.
CONCLUSIONS:Variations in the urinary concentrations of lead and selenium were associated with blood pressure at low levels of exposure/intake.