The association between urinary bisphenol A levels and nonalcoholic fatty liver disease in Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017.
10.1186/s12199-021-01010-7
- Author:
Sang Joon AN
1
;
Eun-Jung YANG
2
;
Subin OH
3
;
Kyong Jin PARK
3
;
Taehyen KIM
3
;
Yeon-Pyo HONG
4
;
Yun-Jung YANG
5
Author Information
1. Department of Neurology, Catholic Kwandong University International St Mary's Hospital, Incheon, 22711, Republic of Korea.
2. Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
3. College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do, 25601, Republic of Korea.
4. Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, 06974, Republic of Korea.
5. Institute of Biomedical Science, Catholic Kwandong University International St. Mary's Hospital, Incheon, 22711, Republic of Korea. yangyj@ish.ac.kr.
- Publication Type:Journal Article
- Keywords:
Bisphenol A;
Hepatic steatosis index;
Korean adults;
Korean national environmental health survey;
Nonalcoholic fatty liver disease
- MeSH:
Asians;
Benzhydryl Compounds/urine*;
Environmental Exposure;
Environmental Health;
Female;
Health Surveys;
Humans;
Male;
Middle Aged;
Non-alcoholic Fatty Liver Disease/epidemiology*;
Phenols/urine*;
Republic of Korea/epidemiology*
- From:Environmental Health and Preventive Medicine
2021;26(1):91-91
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is becoming a global health problem. Bisphenol A (BPA), one of most widely used environmental chemicals, is suspected to be a contributor to the development NAFLD. This study was performed to examine the relationship between human BPA levels and risk of NAFLD.
METHODS:The data (n = 3476 adults: 1474 men and 2002 women) used in this study were obtained from the Korean National Environmental Health Survey III (2015-2017). BPA levels were measured in urine samples. NAFLD was defined using hepatic steatosis index after exclusion of other causes of hepatic diseases.
RESULTS:There was a significant linear relationship between the elevated urinary BPA concentrations and risk of NAFLD. In a univariate analysis, odds ratio (OR) of the highest quartile of urinary BPA level was 1.47 [95% confidence interval (CI) 1.11-1.94] compared to the lowest quartile. After adjusted with covariates, the ORs for NAFLD in the third and fourth quartiles were 1.31 [95% CI 1.03-1.67] and 1.32 [95% CI 1.03-1.70], respectively.
CONCLUSIONS:Urinary BPA levels are positively associated with the risk of NAFLD in adults. Further experimental studies are needed to understand the molecular mechanisms of BPA on NAFLD prevalence.
