Transcutaneous electrical acupoint stimulation improves pregnancy outcomes of in vitro fertilization- embryo transfer : A meta-analysis of randomized controlled trials.
- Author:
Xu-Xin ZHAN
1
;
Hong-Cai CAI
2
;
Yong WANG
3
;
Jing ZHAO
1
;
Jiang GOU
1
;
Wei QU
1
;
Dun-Sheng MO
4
Author Information
1. Department of Reproductive Medicine, Xi'an Peoples' Hospital (Xi'an Fourth Hospital), Xi'an, Shaanxi 710004, China.
2. Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
3. Wangyong Clinic of Traditional Chinese Medicine, Xi'an, Shaanxi 710500, China.
4. Department of Urology, Liuzhou Workers' Hospital / The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545005, China.
- Publication Type:Meta-Analysis
- Keywords:
clinical pregnancy rate;
implantation rate;
in vitro fertilization-embryo transfer;
live birth rate;
meta-analysis;
transcutaneous electrical acupoint stimulation
- MeSH:
Acupuncture Points;
Embryo Transfer;
Female;
Fertilization in Vitro;
Humans;
Pregnancy;
Pregnancy Outcome;
Randomized Controlled Trials as Topic
- From:
National Journal of Andrology
2021;27(9):825-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on the pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET) based on the available clinical evidence.
METHODS:We searched PubMed, MEDLINE, EMBASE, Cochrane Library, CNKI, VIP, CBM and Wanfang Database up to February 2021 for published randomized controlled trials (RCT) relevant to TEAS for the improvement of the pregnancy outcomes of IVF-ET. We performed literature screening, data extraction and quality evaluation according to the inclusion and exclusion criteria, followed by a meta-analysis with the RevMan 5.3 software.
RESULTS:A total of 2 206 cases of IVF-ET from 9 RCTs were included, 1 018 in the TEAS group and 1 188 in the control. The clinical pregnancy rate was significantly higher in the TEAS than in the mock TEAS and non-TEAS control groups (RR = 1.85, 95% CI: 1.42－2.42, P < 0.001; RR = 1.23, 95% CI: 1.10－1.39, P = 0.0004), and so was it before and after oocyte retrieval (RR = 1.50, 95% CI: 1.03－2.17, P = 0.03; RR = 1.47, 95% CI: 1.12－1.92, P = 0.005). The TEAS group also showed dramatically improved embryo implantation rate (RR = 1.49, 95% CI: 1.24－1.79, P < 0.0001) and live birth rate (RR = 1.44, 95% CI: 1.04－1.98, P = 0.03) compared with the control.
CONCLUSIONS:As a safe and non-invasive treatment, TEAS can significantly improve the pregnancy outcomes of IVF-ET, with definite effectiveness. /.
