Progress in the Mechanism of Lymphangiogenesis and Lymphatic Metastasis
of Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2021.101.42
- Author:
Xiayao DIAO
1
;
Chao GUO
1
;
Shanqing LI
1
Author Information
1. Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
- Publication Type:Review
- Keywords:
Lung neoplasms;
Lymphangiogenesis;
Lymphatic metastasis;
Non-coding RNA;
Tumor microenvironment
- MeSH:
Carcinoma, Non-Small-Cell Lung/genetics*;
Disease Progression;
Endothelial Cells;
Humans;
Lung Neoplasms/genetics*;
Lymphangiogenesis;
Lymphatic Metastasis;
Lymphatic Vessels;
Tumor Microenvironment;
Vascular Endothelial Growth Factor C
- From:
Chinese Journal of Lung Cancer
2021;24(12):874-880
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer ranks the first cancer-related morbidity and mortality in China. Tumor metastasis always predicts the poor prognosis for patients. Moreover, lymphatic metastasis is one of the most significant predictors of poor prognosis in patients with non-small cell lung cancer (NSCLC) and lymphangiogenesis represents the bridge that functionally facilitates tumor lymphatic metastasis. In this review, we first discussed the molecular mechanisms of tumor-associated lymphangiogenesis and the interaction between tumor microenvironment and lymphatic endothelial cells, then, summarized the role of non-coding RNA in regulating tumor-associated lymphangiogenesis in recent frontier studies, with the aim to provide some novel insights on NSCLC-related lymphangiogenesis research, diagnosis and treatment.
.
