Advances in Molecular Typing of Small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2021.101.36
- Author:
Mengyuan XU
1
;
Junwen ZHANG
1
;
Yanjun SU
2
;
Xichuan LI
1
Author Information
1. Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin 300387, China.
2. Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy, Department of Lung Cancer,
Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Disease treatment;
Lung neoplasms;
Molecular typing
- MeSH:
Humans;
Lung Neoplasms/genetics*;
Molecular Typing;
Quality of Life;
Small Cell Lung Carcinoma/genetics*;
Transcription Factors
- From:
Chinese Journal of Lung Cancer
2021;24(10):734-738
- CountryChina
- Language:Chinese
-
Abstract:
Small cell lung cancer (SCLC) is a highly aggressive and fatal malignant tumor. It has the characteristics of complex etiology, low differentiation, high malignancy, fast growth, strong invasiveness, early metastasis and acquired drug resistance, resulting in poor prognosis. In recent years, with the gradual deepening understanding on the molecular mechanism of SCLC and multi-omics data, it is proposed that molecular typing can be carried out according to the differential expression of key transcription factors, including SCLC-A, SCLC-N, SCLC-P and SCLC-I subtypes. Molecular typing of SCLC and its clinical application will help doctors to further optimize the detailed diagnosis and treatment plan of SCLC patients, so as to prolong the survival time and improve the quality of life of patients.
.
