Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts.
10.1007/s11655-021-3495-2
- Author:
Teng-da WANG
1
;
Song-Lin XU
1
;
Zheng-Yi YU
1
;
Shao-Bin NI
1
;
Cheng ZHANG
1
;
Zhi-Xing JIAO
2
Author Information
1. Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
2. Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150000, China. jiaozhixing@foxmail.com.
- Publication Type:Journal Article
- Keywords:
Nrf2-ARE-HO-1 signaling pathway;
arsenic trioxide;
infiltration;
inflammation;
leflunomide;
xenotransplantation
- MeSH:
Animals;
Arsenic Trioxide;
Cricetinae;
Heart Transplantation;
Heme Oxygenase-1/metabolism*;
Heterografts;
Leflunomide;
NF-E2-Related Factor 2/metabolism*;
Rats;
Rats, Inbred Lew;
Signal Transduction
- From:
Chinese journal of integrative medicine
2021;27(10):760-766
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the molecular mechanisms underlying the effects of arsenic trioxide (As
METHODS:Transplantation of LVG hamster hearts to Lewis rats was performed by anastomosis of vessels in the neck using end-to-end anastomosis with a non-suture cuff technique. Four groups of recipient rats (n=6 in each) were treated with normal saline (control), As
RESULTS:Expression of Nrf2-ARE-HO-1 signaling pathway was upregulated in heart xenografts in rats treated with As
CONCLUSION:Combination treatment with As
