Antitumor Effects of Ethanol Extract from Ventilago leiocarpa Benth on Sarcoma 180 Tumor-Bearing Mice and Possible Immune Mechanism.
10.1007/s11655-021-3440-4
- Author:
Dao-Hai CHENG
1
;
Ying LIU
2
;
Li WANG
3
Author Information
1. Department of Pharmacy, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
2. Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, 530022, China. shenghuakai_1997@163.com.
3. Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, 530022, China.
- Publication Type:Journal Article
- Keywords:
Bcl-2;
Chinese folk medicine;
Ventilago leiocarpa Benth;
Yao medicine;
antitumor effect;
caspase-3;
immune function
- MeSH:
Animals;
Cell Line, Tumor;
Ethanol;
Mice;
Plant Extracts/therapeutic use*;
Rhamnaceae;
Sarcoma 180/drug therapy*
- From:
Chinese journal of integrative medicine
2021;27(12):905-911
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To explore the antitumor effects of ethanol extract from Ventilago leiocarpa Benth (EEVLB) on sarcoma 180 (S180) tumor-bearing mice and the potential mechanism.
METHODS:Sixty mice were randomly assigned to 6 groups according to a random number table: normal group, model group, 5-fluorouracil (5-FU) group (0.02 g·kg
RESULTS:EEVLB with different concentrations achieved inhibition of tumor growth in vivo, wherein the high-dose group showed the most significant reduction in tumor weight and increased apoptosis of tumor cells (P<0.05). In addition, both net weight gain and spleen index of mice showed uptrend in EEVLB treatment groups (P<0.05). Besides, serum levels of IL-2 and IL-6, percentages of CD3
CONCLUSIONS:EEVLB exhibits promising antitumor activity in vivo. This effect might be due to activation of apoptotic signaling pathway, increase of cytokine levels and enhancement of immune function in tumor-bearing mice.
