Research progress on screening of pregnancy-related diseases based on fetal cell free DNA.
10.3760/cma.j.cn511374-20200803-00577
- Author:
Jianan LIU
1
;
Geng AN
;
Yanhui LIU
Author Information
1. Reproductive Medicine Center, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China. liuliang71215@163.com.
- Publication Type:Review
- MeSH:
Cell-Free Nucleic Acids/genetics*;
Female;
Fetus;
Humans;
Placenta;
Pregnancy;
Pregnancy Complications;
Pregnancy Outcome
- From:
Chinese Journal of Medical Genetics
2021;38(10):1025-1029
- CountryChina
- Language:Chinese
-
Abstract:
Fetal cell free DNA (cfDNA) in maternal blood circulation mainly originates from placental trophoblasts which have dual characteristics of apoptotic cells and the embryo, and can be affected by maternal factors. Pregnancy-related diseases including preeclampsia, gestational diabetes mellitus, preeclampsia, macrosomia and fetal growth restriction can seriously affect maternal health and pregnancy outcome. Early prediction and timely intervention are important means to reduce the risk. Fetal cfDNA and prediction of pregnancy-related diseases have become a hot topicfor current research. This paper reviews the latest progress made in the field.
