Serum Ferritin and Metabolic Syndrome in Perimenopausal and Postmenopausal Women.
10.6118/jksm.2011.17.3.166
- Author:
Soo Hyun CHO
1
Author Information
1. Department of Family Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. soohu@hanmail.net
- Publication Type:Original Article
- Keywords:
Atherosclerosis;
Cardiovascular diseases;
Ferritins;
Metabolic Syndrome;
Postmenopause;
Women
- MeSH:
Alanine Transaminase;
Aspartate Aminotransferases;
Atherosclerosis;
C-Reactive Protein;
Cardiovascular Diseases;
Female;
Ferritins;
Hemoglobins;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Linear Models;
Lipoproteins;
Postmenopause;
Uric Acid
- From:The Journal of Korean Society of Menopause
2011;17(3):166-173
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to examine the relationship between serum ferritin and metabolic syndrome in peri- and postmenopausal women. METHODS: The study subjects consisted of 2,091 peri- and postmenopausal women who visited the hospital for a health check-up in 2007. They were divided into the metabolic syndrome group (MetS) and the non-metabolic syndrome group (Non-MetS). RESULTS: Mean serum ferritin values were 65.16 +/- 33.69 ng/mL in MetS and 57.82 +/- 32.51 ng/mL in Non-MetS (P = 0.000). In MetS, serum ferritin had a positive correlation with hemoglobin (Hb), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, aspartate transaminase (SGOT), alanine transaminase (SGPT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) but a negative correlation with high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol (P < 0.05). From multiple linear models, hs-CRP, HDL-cholesterol, SGOT, HOMA-IR, and hemoglobin level were found to be the best predictors of serum ferritin in MetS (R 2 = 0.106; P < 0.05). CONCLUSION: The serum ferritin level in MetS was higher than in Non-MetS in postmenopausal women. In MetS, with increasing hs-CRP, SGOT, HOMA-IR, and hemoglobin levels and decreasing HDL-cholesterol levels, the serum ferritin level seems to increase
