Effects of Chronic Alcohol Consumption on Midazolam Induced Sedation during Colonoscopy.
- Author:
Young Sook PARK
1
;
Jong Yong LEE
;
Yu Seoung SEO
;
Chung Hyeon KIM
;
Jung Don LEE
;
Hyun Suk LEE
;
Kye Hyung KWON
;
Tae Hun KIM
;
Yun Ju JO
Author Information
1. Department of Gastroenterology, Eulji University School of Medicine, Nowon Eulji Medical Center, Seoul, Korea. pys1109@eulji.or.kr
- Publication Type:Original Article
- Keywords:
Alcohol;
Conscious sedation;
Colonoscopy;
Midazolam;
Induction time
- MeSH:
Alcohol Drinking*;
Amnesia;
Colonoscopy*;
Conscious Sedation;
Consciousness;
Humans;
Midazolam*;
Outpatients;
Prospective Studies
- From:Korean Journal of Gastrointestinal Endoscopy
2004;29(6):495-499
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: It is suggested that patients consuming large amounts of alcohol are difficult to be sedated by midazolam probably due to cross tolerance. We studied to know the adequate administration doses of midazolam in patients with chronic alcohol consumption. METHODS: Study I; We prospectively studied 117 outpatients presenting for colonoscopy. According to alcohol consumption we divided four groups such as group I: 0 g/day, group II: <10 g/day, group III: 10~40 g/day, group IV: >40 g/day. We initially administered 0.06 mg/kg midazolam and add up to spontaneous eye closure. We measured grade of amnesia, level of consciousness, endoscopist's assessment and VAS scale for pain after recovery. Study II; We measured induction time after 0.08 mg/kg midazolam in 60 patients who drink alcohol. RESULTS: Additional amount of midazolam was not significantly different between the groups (group I: 0.0145 mg/ kg, group II: 0.0214 mg/kg, group III: 0.0181 mg/kg, group IV: 0.0199 mg/kg). There were no differences of sedation parameters between the groups. However the induction time was prolonged and correlated with alcohol consumption. CONCLUSIONS: For adequate sedation in patients with chronic alcohol consumption, longer induction time rather than increasing dosage is required.
