New deafness gene: Progress of research on ABCC1 in biological barriers.
10.3760/cma.j.cn511374-20200519-00356
- Author:
Shuai ZHANG
1
;
Jie LING
;
Meng LI
;
Lingyun MEI
Author Information
1. Department of Ear, Nose, Throat, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. entmly@163.com.
- Publication Type:Review
- MeSH:
Biological Transport;
Deafness/genetics*;
Female;
Humans;
Male;
Multidrug Resistance-Associated Proteins/genetics*;
Placenta;
Pregnancy
- From:
Chinese Journal of Medical Genetics
2021;38(9):907-911
- CountryChina
- Language:Chinese
-
Abstract:
ABCC1 gene is expressed in various tissues and organs of the human body, and can transport substrates including drugs, heavy metals, toxic substances and organic anions. Previous research on ABCC1 gene has mostly focused on tumor multidrug resistance. Recently, ABCC1 has been proposed as a candidate gene for hereditary hearing impairment, which has attracted much attention. ABCC1-associated deafness may be related to its role in biological barriers. This article has summarized recent progress in the study of the role of ABCC1 in the blood-testis barrier, placental barrier, blood-brain barrier, blood-labyrinth barrier, which may provide insight into its biological functions.
