Does Prior Cancer Have an Influence on the Survival Outcomes of Patients with Localized Pancreatic Neuroendocrine Tumors?
- Author:
Liang WANG
1
;
Gang LI
1
;
Yun-Tao BING
1
;
Mao-Lin TIAN
1
;
Hang-Yan WANG
1
;
Chun-Hui YUAN
1
;
Dian-Rong XIU
1
Author Information
- Publication Type:Journal Article
- Keywords: pancreatic neuroendocrine tumor; prior cancer; propensity score matching
- MeSH: Aged; Female; Humans; Male; Multivariate Analysis; Neoplasms, Second Primary; Neuroendocrine Tumors/epidemiology*; Pancreatic Neoplasms/epidemiology*; Propensity Score
- From: Chinese Medical Sciences Journal 2021;36(4):284-294
- CountryChina
- Language:English
- Abstract: Objective To investigate the impact of prior non-pancreatic cancer on the survival outcomes of patients with localized pancreatic neuroendocrine tumors (PanNETs). Methods We reviewed the Surveillance, Epidemiology, and End Results database and selected patients with localized PanNETs diagnosed between 1973 and 2015. We divided the patients into two groups according to the presence or absence of prior non-pancreatic malignancy. Before and after propensity score matching, we compared the clinicopathological characteristics and studied the overall survival and cancer-specific survival. Results A total of 357 (12.9%) of 2778 patients with localized PanNETs had prior cancer. A total of 1211 cases with only a localized PanNET and 133 cases with a localized PanNET and prior cancer had complete data and met the inclusion criteria of the current study. Patients with prior cancer were associated with advanced age (>65 years, 57.9% prior cancer
