Adiponectin Ameliorated Pancreatic Islet Injury Induced by Chronic Intermittent Hypoxia through Inhibiting the Imbalance in Mitochondrial Fusion and Division.

Author: Can HE ¹ ; Xi-Long ZHANG ^{2
,

3} ; Qiang ZHANG ¹ ; Lu-Yao GE ¹ ; Wen-Xiao DING ¹
Author Information

1. Department of Pulmonary and Critical Care Medicine, Zhongda Hospital, School of Medicine Southeast University, Nanjing 210009, China.
2. Department of Pulmonary and Critical Care Medicine, the First Affiliated
3. Hospital, Nanjing Medical University, Nanjing 210029, China.
Publication Type:Journal Article
Keywords: adiponectin; chronic intermittent hypoxia; mitochondrial fusion and division; obstructive sleep apnea hypopnea syndrome; pancreatic islet
MeSH: Adiponectin/genetics*; Animals; Hypoxia; Islets of Langerhans; Mitochondrial Dynamics; Rats; Rats, Wistar
From: Chinese Medical Sciences Journal 2021;36(3):225-233
CountryChina
Language:English
Abstract: Objective This study aimed to assess the protective value of adiponectin (APN) in pancreatic islet injury induced by chronic intermittent hypoxia (CIH). Methods Sixty rats were randomly divided into three groups: normal control (NC) group, CIH group, and CIH with APN supplement (CIH+APN) group. After 5 weeks of CIH exposure, we conducted oral glucose tolerance tests (OGTT) and insulin released test (IRT), examined and compared the adenosine triphosphate (ATP) levels, mitochondrial membrane potential (MMP) levels, reactive oxygen species (ROS) levels, enzymes gene expression levels of