Research of relationship between frailty and gut microbiota on middle-aged and the aged patients with diabetes.

Author: Xuchao PENG ¹ ; Yanli ZHAO ¹ ; Taiping LIN ¹ ; Xiaoyu SHU ¹ ; Lisha HOU ¹ ; Langli GAO ¹ ; Hui WANG ¹ ; Ning GE ¹ ; Jirong YUE ¹
Author Information

1. Department of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.
Publication Type:Journal Article
Keywords: diabetes; frailty; gut microbiota; metagenomics sequencing; microbiota analysis
MeSH: Aged; Diabetes Mellitus; Epstein-Barr Virus Infections; Frailty; Gastrointestinal Microbiome; Herpesvirus 4, Human; Humans; Middle Aged
From: Journal of Biomedical Engineering 2021;38(6):1126-1133
CountryChina
Language:Chinese
Abstract: Gut microbiota plays an important role in development of diabetes with frailty. Therefore, it is of great significance to study the structural and functional characteristics of gut microbiota in Chinese with frailty. Totally 30 middle-aged and the aged participants in communities with diabetes were enrolled in this study, and their feces were collected. At the same time, we developed a metagenome analysis to explore the different of the structural and functional characteristics between diabetes with frailty and diabetes without frailty. The results showed the alpha diversity of intestinal microbiota in diabetes with frailty was lower.