Steroidogenic acute regulatory protein-related lipid transfer 4 (StarD4) promotes breast cancer cell proliferation and its mechanism.
10.7507/1001-5515.202105008
- Author:
Teng HUANG
1
;
Rong SHAN
1
;
Min ZHANG
1
;
Ling LI
2
;
Juan HUANG
3
;
Baoan LIU
4
;
Weibing ZHOU
1
Author Information
1. Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, P.R.China.
2. Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha 410008, P.R.China.
3. Hunan Province Clinic Meditech Research Center for Breast Cancer, Xiangya Hospital, Central South University, Changsha 410008, P.R.China.
4. Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, P.R.China.
- Publication Type:Journal Article
- Keywords:
ITGA5;
StarD4;
cholesterol metabolism;
triple negative breast cancer
- MeSH:
Breast Neoplasms/genetics*;
Cell Line, Tumor;
Cell Proliferation;
Female;
Humans;
Lipids;
Membrane Transport Proteins;
Phosphoproteins
- From:
Journal of Biomedical Engineering
2021;38(6):1118-1125
- CountryChina
- Language:Chinese
-
Abstract:
Oncogene StarD4 had the function of promoting proliferation and metastasis of triple-negative breast cancer (TNBC), but its clinical value and molecular mechanism are unknown. This paper found that StarD4 was highly expressed in cancer tissues of TNBC patients, and higher expression level of StarD4 in TNBC patient resulted in poorer prognosis. Based on transcriptomics of MDA-MB-231 cell model, the results of bioinformatics analysis showed that down-regulated expression level of StarD4 led to overall downregulation of cholesterol-relative genes and significant enrichment of cancer mechanism and pathway. Further analysis and investigation verified that StarD4 might cross-promote the protein stability of receptor ITGA5 through the cholesterol pathway to enhance TNBC progression, which provides guidance for clinical application of TNBC diagnosis and treatment.
