Local administration of parathyroid hormone and parathyroid hormone-related peptides for bone tissue engineering.
10.7507/1001-5515.202104045
- Author:
Zhuowen HAO
1
;
Jingfeng LI
1
Author Information
1. Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital, Wuhan University, Wuhan 430071, P.R.China.
- Publication Type:Review
- Keywords:
bone healing;
bone regeneration;
local delivery strategies;
parathyroid hormone;
parathyroid hormone-related peptides
- MeSH:
Bone and Bones;
Parathyroid Hormone;
Tissue Engineering;
Tissue Scaffolds;
Wound Healing
- From:
Journal of Biomedical Engineering
2021;38(5):1028-1034
- CountryChina
- Language:Chinese
-
Abstract:
Parathyroid hormone (PTH) exerts multiple effects such as regulating bone remodeling, promoting angiogenesis, etc., and it is an active factor with great application potential for bone repair. In recent years, with the development of scaffold material loading strategies and parathyroid hormone-related peptides (PTHrPs), in situ loading of PTH or PTHrPs on scaffold materials to promote bone defect healing gradually becomes possible. Based on the current status and challenges of intermittent PTH (iPTH) for bone tissue engineering, the review summarizes the in-situ application strategies of PTH and the construction of PTHrPs as well as current problems and further directions in this field, with a view to propel the clinical application of scaffold materials loaded with PTH or PTHrPs
