A photothermal/chemotherapy injectable paclitaxel gel with irradiation stability.
10.7507/1001-5515.202011087
- Author:
Yaowen OUYANG
1
;
Kui ZHANG
1
;
Liangqin ZHOU
1
;
Yuanwei CHEN
1
;
Xianglin LUO
1
Author Information
1. College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, P.R.China.
- Publication Type:Journal Article
- Keywords:
injectable drug gel;
photothermal cycle stability;
photothermal-chemotherapy combination;
tumor therapy
- MeSH:
Animals;
Cell Line, Tumor;
Gels;
Hyperthermia, Induced;
Mice;
Mice, Inbred BALB C;
Nanoparticles;
Paclitaxel;
Phototherapy
- From:
Journal of Biomedical Engineering
2021;38(5):979-985
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study is to construct an injectable gel with stable phototherapy and chemotherapy. Res-PTX@IR780 gel with phototherapy and chemotherapy property was prepared by introduction of photosensitizer IR780 and antioxidant resveratrol (Res) into the polyethylene glycol (PEG) solution of paclitaxel (PTX). The results showed that PTX, PTX@IR780 and Res-PTX@IR780 could form gels and the gels were injectable. ATR-FTIR results indicated not only components of the gels but also the formation of hydrogen bonding during the gelation. The results of UV showed instability of IR780 solution and stability improvement of Res-IR780 solution under infrared radiation (IR) irradiation. Photothermal tests showed that Res-PTX@IR780 displayed better photothermal conversion and photothermal stability under multiple irradiations than PTX@IR780. The results of
