A new cembranoid diterpene from Olibanum.
10.19540/j.cnki.cjcmm.20210702.203
- Author:
Zhi-Chao CHEN
1
;
Fang-You CHEN
1
;
Wei-Ming HUANG
1
;
Yu-Ting BIAN
1
;
Yong-Ming LUO
1
Author Information
1. School of Pharmacy, Jiangxi University of Chinese Medicine Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
Olibanum;
cembranoid diterpene;
chemical composition;
neurotoxicity
- MeSH:
Chromatography, High Pressure Liquid;
Diterpenes;
Frankincense;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2021;46(24):6417-6421
- CountryChina
- Language:Chinese
-
Abstract:
Five compounds were isolated from the alcohol extract of Olibanum by MCI, silica gel, ODS, and Sephadex LH-20 column chromatographies and preparative high-performance liquid chromatography(HPLC). On the basis of spectral data and literature data, the compounds were identified as:(1S,3R,4S,7R,11S,12R)-1:12,4:7-diepoxisonane-8(19)-ene-3,11-diol(1), boscartin A(2),(+)-resinolin(3),(+)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one(4), and acerogenin A(5). Compound 1 is a new compound, and compounds 3-5 were isolated from Olibanum for the first time. The structure of compound 1 was determined by spectroscopic analysis and single-crystal X-ray diffraction. Compounds 1 and 2 were tested for PC12 neurotoxicity, and the results showed that they were both safe compounds.
