Expression of c-Met in ovarian epithelial tumor.
- Author:
Bo Seop KIM
1
;
Il Soo PARK
;
Yoon Soon LEE
;
Tae Bon KOO
;
Tae In PARK
Author Information
1. Depatment of Obsterics and Gynocology, Kyungpook National University College of Medicine, Daegu, Korea. parkis@knu.ac.kr
- Publication Type:Original Article
- Keywords:
c-Met;
Epithelial ovarian cancer;
Prognosis
- MeSH:
Adenocarcinoma;
Humans;
Ovarian Neoplasms;
Prognosis
- From:Korean Journal of Gynecologic Oncology
2007;18(4):284-288
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study was performed to evaluate the expression of c-Met in epithelial ovarian carcinoma. METHODS: Paraffin-embedded tissues from 50 epithelial ovarian adenocarcinomas were stained immunohistochemically for c-Met expression. The expression of c-Met was correlated with clinicopathologic parameters including, histologic type, tumor size, and tumor stage. RESULTS: c-Met expression was found in 29 cases (58%) among 50 ovarian cancers. In clinicopathologic study, c-Met expression of epithelial ovarian carcinomas did not show the correlation with clinicopathologic parameters such as histologic type, tumor size and stage. CONCLUSION: c-Met expression might be a potential prognostic marker for patients with advanced stage epithelial ovarian cancers. However, larger population-based studies should be performed to determine the prognostic potential of c-Met expression in advanced ovarian carcinoma.
