Advance in mechanisms of glial scarring after stroke and intervention of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20210901.702
- Author:
Ji-Yong LIU
1
;
Jun LIAO
2
;
Rui FANG
3
;
Jin-Wen GE
3
;
Zhi-Gang MEI
3
Author Information
1. Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine Changsha 410208, China.
2. Medical School, Hunan University of Chinese Medicine Changsha 410208, China.
3. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine Changsha 410208, China.
- Publication Type:Journal Article
- Keywords:
NG2 glial cell;
astrocytes;
glial scar;
microglia;
stroke;
traditional Chinese medicine
- MeSH:
Astrocytes;
Axons/pathology*;
Cicatrix/pathology*;
Gliosis/pathology*;
Humans;
Medicine, Chinese Traditional;
Nerve Regeneration;
Stroke/drug therapy*
- From:
China Journal of Chinese Materia Medica
2021;46(23):6139-6148
- CountryChina
- Language:Chinese
-
Abstract:
When ischemia or hemorrhagic stroke occurs, astrocytes are activated by a variety of endogenous regulatory factors to become reactive astrocytes. Subsequently, reactive astrocytes proliferate, differentiate, and migrate around the lesion to form glial scar with the participation of microglia, neuron-glial antigen 2(NG2) glial cells, and extracellular matrix. The role of glial scars at different stages of stroke injury is different. At the middle and late stages of the injury, the secreted chondroitin sulfate proteoglycan and chondroitin sulfate are the main blockers of axon regeneration and nerve function recovery. Targeted regulation of glial scars is an important pathway for neurological rehabilitation after stroke. Chinese medicine has been verified to be effective in stroke rehabilitation in clinical practice, possibly because it has the functions of promoting blood resupply, anti-inflammation, anti-oxidative stress, inhibiting cell proliferation and differentiation, and benign intervention in glial scars. This study reviewed the pathological process and signaling mechanisms of glial scarring after stroke, as well as the intervention of traditional Chinese medicine upon glial scar, aiming to provide theoretical reference and research evidence for developing Chinese medicine against stroke in view of targeting glial scarring.
