Construction of pharmacophore model and its application in identification of effective components of Chinese medicine.
10.19540/j.cnki.cjcmm.20210630.601
- Author:
Wen-Jin ZHANG
1
;
Ye CAO
2
;
Li-Kun CHANG
3
;
Sheng WANG
1
;
Chuan-Zhi KANG
1
;
Li ZHOU
1
;
Lan-Ping GUO
1
Author Information
1. National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China.
3. National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China School of Traditional Chinese Medicine, Guangdong Pharmaceutical University Guangzhou 510006, China.
- Publication Type:Systematic Review
- Keywords:
active component identification;
pharmacophore;
virtual screening
- MeSH:
Drug Design;
Drugs, Chinese Herbal;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2021;46(23):6130-6138
- CountryChina
- Language:Chinese
-
Abstract:
The effective material basis of Chinese medicine is the key and difficult point in the quality control and modernization research of Chinese medicine. With the increasing application of pharmacophore-based virtual screening in computer-aided drug design, it is possible to employ this technology in the modernization of Chinese medicine. Based on the systematic research method of the pharmacophore model, the present study systematically reviewed the pharmacophore-based technologies and strategies in the identification of active components in Chinese medicine.
