Rb pathway alteration and E2F-1 expression in epithelial ovarian cancer.
- Author:
Sung Hee KIM
1
;
Soo Hyeon MOON
;
Su Il SHIN
;
Dong Soo SUH
;
Man Soo YOON
;
Kyung Un CHOI
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Epithelial ovarian cancer;
Rb pathway alteration;
E2F-1 expression
- MeSH:
Mitotic Index;
Ovarian Neoplasms*
- From:Korean Journal of Gynecologic Oncology
2007;18(4):299-307
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the clinicopathological implications of Rb pathway alteration and E2F-1 expression in Epithelial ovarian cancer using immunohistochemical staining. METHODS: Tissue samples (n=72) were collected after staging operation between 1998 and 2004. RESULTS: In 72 cases, the overall expression of pRb, and E2F-1 were 59.7% (43/72), and 58.3% (42/72), respectively. pRb expression was inversely correlated with stage, histologic grade and mitotic index. E2F-1 expression was correlated with advanced stages, high grade, mitotic index, Ki-67 labeling index (LI). CONCLUSION: We suggest that Rb pathway alteration and E2F-1 expression could play roles as a new prognostic factors in Epithelial ovarian cancer.
