Particle design for improving content uniformity of Hewei Jiangni Capsules.
10.19540/j.cnki.cjcmm.20211015.301
- Author:
Wei MEI
1
;
Liang FENG
2
;
Ya-Jun SHI
1
;
Jun-Bo ZOU
1
;
Xiao-Fei ZHANG
1
;
Zong-Ping ZHAO
3
;
Dong-Yan GUO
1
;
Xiao-Bin JIA
2
Author Information
1. Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy,Shaanxi University of Chinese Medicine Xianyang 712046, China.
2. School of Traditional Chinese Pharmacy,China Pharmaceutical University Nanjing 211198, China.
3. Shaanxi Weixin Pharmaceutical Co., Ltd. Xi'an 710065, China.
- Publication Type:Journal Article
- Keywords:
Hewei Jiangni Capsules;
composite particles;
particle design;
super-fine grinding;
uniformity
- MeSH:
Capsules;
Microscopy, Electron, Scanning;
Particle Size;
Powders
- From:
China Journal of Chinese Materia Medica
2021;46(23):6045-6052
- CountryChina
- Language:Chinese
-
Abstract:
Targeting the poor powder characteristics of the contents in Hewei Jiangni Capsules, this study characterized the powder properties of the contents and employed particle design technique for improving the content quality. The content composite particles of Hewei Jiangni Capsules prepared by the particle design technique were evaluated by scanning electron microscopy(SEM), followed by infrared ray(IR), content uniformity, and in vitro dissolution detection. It was found that there was a good correlation between the crushed particle size of slices and the crushing time, and the calcined Haematitum was responsible for the poor content uniformity. After the fine powder of calcined Haematitum was super-finely ground for 8.5 min and those of the other contents in the capsule for 1 min, they were prepared into the composite particles, whose property characterizations were compared with those of the physical mixtures. The content uniformity of the prepared composite particles was significantly improved, and the preparation process was stable and reliable. The adoption of particle design technology to correct the poor uniformity of the physical mixture, solve the pharmaceutical defects of Hewei Jiangni Capsules, and improve the quality of prescriptions has provided important reference for the clinical application and development of Chinese medicinal preparations.
