Application of design technology for preparing Lingzhu Powder particles based on solvent evaporation method.
10.19540/j.cnki.cjcmm.20211015.303
- Author:
Xiao ZHOU
1
;
Liang FENG
2
;
Xiao-Fei ZHANG
1
;
Yan-Jun YANG
1
;
Xiao-Bin JIA
2
;
Jun-Bo ZOU
1
;
Ya-Jun SHI
1
Author Information
1. Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine Xianyang 712046, China.
2. School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.
- Publication Type:Journal Article
- Keywords:
Lingzhu Powder;
composite particles;
particle design technology;
powder properties;
solvent evaporation method
- MeSH:
Particle Size;
Powders;
Solvents;
Technology
- From:
China Journal of Chinese Materia Medica
2021;46(23):6028-6034
- CountryChina
- Language:Chinese
-
Abstract:
Targeting the deficiencies of Lingzhu Powder, this study introduced the particle design technology to improve its quality. Based on the mechanism of particle design for powder and the characteristics of solvent evaporation method, composite particles consisting of Succinum, Cinnabaris, and artificial Bovis Calculus were prepared. And the powder properties of composite particles and physical mixtures as well as the content uniformity of toxic components were investigated for exploring the technological advantages of particle design in improving the quality of Lingzhu Powder. The results showed that the composite particles prepared using solvent evaporation method and particle design technology were micro-particles, and the stable agglomerate structure could be observed under SEM. Composite particles exhibited better fluidity and compliance in oral intake than physical mixtures. The differences in chromatism, bulk density, and content uniformity of the composite particles were smaller than those of physical mixtures, and the corresponding RSD values \[4.8%, 1.8%, 3.4%(bilirubin), and 0.63%(HgS), respectively\] were smaller. The solvent evaporation combined with particle design technology can be utilized to significantly improve the quality of Lingzhu Powder, which has provided new ideas for the optimization of the quality of traditional Chinese medicinal powder.
